Surface-modified Magnesium Hydroxide Nanoparticles Augment Physico-Mechanical and Biological Properties of PLLA Composites
발표자
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초록
내용
Biodegradable poly(L-lactic acid) (PLLA) has attracted a great deal of attention as biomedical materials. However, it has some drawbacks such as lower hydrophilicity, slow degradation rate, and acidic degradation product that causes inflammatory response. In this study, the PLLA composites with two surface-modified nanoparticle magnesium hydroxide (nMH) with totally different topological structure were prepared to enhance the physico-mechanical and biological properties. The incorporation of surface-modified nMH not only enhanced mechanical properties but also improved homogeneity of magnesium hydroxide particles in the PLLA matrix. Additionally, the PLLA composites with surface-modified nMH reduced cytotoxicity and immunogenicity, and increased hemocompatibility. This study suggests a new platform in designing a biodegradable cardiovascular implant including stents with improved thermal and mechanical properties and reduced inflammatory response.