Degradation behavior of poly(lactide-co-glycolide) monolayers by Langmuir technique
발표자
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초록
내용
Bio-degradable PLAs have been attracting much attention because lactide can be produced from renewable resources, such as starch and the degradability of PLA can be controlled by copolymerization with glycolide, ε-caprolactone, or stereochemical LA. Incorporation of hydrophilic glycolide into PLA, poly(lactide-co-glycolide)(PLGA) has been one of the most attractive polymer materials because of its fast biodegradable than PLA due to the absence of methyl group. In this study, a degradation rate of PLGA monolayers was investigated by Langmuir technique as functions of subphase pH and enzyme concentration in the subphase. Although proteinase K is selectively effective to l-LA unit, a composition of PLGA monolayers showed faster enzymatic degradation than l-PLA one.