Design of Mussel-Inspired, Antibacterial Coatings through Non-Biofouling Approach
발표자
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초록
내용
Bacterial colonies (i.e., biofilm) formed on solid surfaces has been recognized as a main cause for hospital-acquired infections, especially in connection with the use of medical diagnostic devices and therapeutic tools/implants that are contaminated by biofilms. To address the issues caused by hospital-acquired infections, we have developed the antibacterial materials that can work as non-biofouling coatings. Inspired by mussel, catechol-conjugated polysaccharides and functional derivatives of 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) were synthesized. The robust antibacterial coatings were accomplished by using oxidative polymerization and the coordination between catechol groups and iron(III) ions. The DOPA-based non-biofouling approach can also be applied for influenza virus immunoassay. We think that our work can serve as a basis to prepare antibacterial coatings for medical diagnostic devices and therapeutic tools.