Improvement of furfuryl gelatin by photo-crosslinking for application to an injectable hydrogel
발표자
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초록
내용
Hydrogels have been widely used for biomedical applications. In particular, injectable hydrogels are attractive due to the fact that it avoids unnecessary incisions. Still, some injectable hydrogels are degraded fast and mechanically weak. We suggested an injectable hydrogel that is cured by visible light, and the mechanical properties were also promoted for practical use. Furfuryl group modified gelatin (f-gel) was synthesized, and the f-gel was cured by visible light with riboflavin phosphate as a photoinitiator. The resultant photo-crosslinked gelatin hydrogel had higher mechanical properties and a slower degradation rate than nonmodified gelatin hydrogel. In addition, BSA was incorporated in the hydrogel matrix as a model protein, and the release profiles were evaluated regarding the gelatin hydrogel concentrations.