Remotely Controllable Nanoengineered Materials for Dynamic Biomedical Engineering
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초록
내용
Developing remotely controllable nanoengineered biomedical materials can regulte and unravel nanoscale and dynamic cell-material interactions at the molecular level. In this talk, I will present the design of nanoengineered biomedical materials that can be remotely controlled by various stimuli, such as magnetic field, light, and self-assembly. I will show ligand stretching, sequencing, alignment, sliding, uncaging, and oscillation to magnetically regulate stem cell adhesion, mechanosensing, and differentiation. I will also show the use of upconversion nanoparticles for near-infrared light-controlled intracellular molecular delivery. I will finally demonstrte the use of nanomaterial self-assembly to regulate the adhesion and release of macrophages and their polarization. We plan to further design novel surface-nanoengineered biomaterials that are remotely controllable for non-toxic and patient-tailorable regenerative and immune engineering.