Nature-inspired adhesive polymers for cardiovascular applications
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Adhesive materials have been attracted for hemostatic agents, wound closure, and other applications towards medical devices and drug delivery platform due to their long-lasting properties in vivo. Polyphenol modification inspired by mussels’ adhesion and plant astringency has been emerging as a strategy to engineer robust, wet-resistant adhesive polymeric materials. Here, we present a variety of polyphenol-modified polymers exhibiting tissue adhesion properties for cardiovascular therapy and advanced 3D printing. First, catechol modification onto chitosan permits unique polymeric phase transition from solid film to adhesive hydrogels, which is applicable to design ‘bloodless needles’ even after injection. Second, tannic acid widely found in plants is spontaneously complexed with proteins for cardiac tissue targeting. Ultimately, these nature-inspired adhesive materials would be useful for developing next generation of medical formulations for drug delivery and tissue repair.