Chitosan-based dual pH and thermal responsive polyelectrolyte hydrogel for colon targeted controlled drug delivery: effect of crosslinker type on drug loading and kinetics release
발표자
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초록
내용
The novel dual pH and thermal responsive hydrogel for colon targeted controlling drug delivery was prepared based on polyelectrolyte network of Polyacrylic acid (PAA) and Norbornene-modified Chitosan (CsNb) simultaneously taken place with chemical cross-linked with bisTetrazine-Poly(N-isopropyl acrylamide) (bisTz-PNIPAM). FTIR, DSC, WAXD and morphological analysis were carried out to demonstrate the successful formation of polyelectrolyte network of –COO- and –NH3+ groups. BisTz-PNIPAM crosslinker performed the outstanding properties in comparison with non-covalent crosslinker and non-polymeric crosslinker system: it inhibited release in acid environment; increased of drug loading content because of more porosity structure and entanglement of PNIPAM chains, and controlled the release based on shrinkage mechanism.