Preparation of non-porous alginate-based hydrogel crosslinked via Diels-Alder Click chemistry for drug release application
발표자
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초록
내용
Alginate-based hydrogels were prepared by Diels-Alder click reaction beween alginate-furfuryl amine (Alg-FA) and disulfide-maleimide crosslinkers (S-Ma). Results showed alginate-based hydrogels having a non-porous morphology, which produced no by-products since gelation was processed via addition reaction between FA and Ma groups. From the drug release test of the hydroges, the fast release continued during the first hour after the initial release test, followed by an extremely slow release till the 10thday. The initial rapid release could be attributed to the dense structure. Moreover, size increment after 10 days indicated the steric hindrance that prevented water molecules from diffusing freely.