Preparation of biodegradable poly(lactic-co-glycolic acid) micro/nanoparticles for vaccination
발표자
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초록
내용
Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible and biodegradable polymer, and PLGA particles have been used extensively for the controlled release of various drugs. In terms of the drug delivery system, PLGA particles can improve vaccinations, cancer treatments, cardiovascular treatments, and regenerative medicine. In diverse applications, the size of the PLGA particle is a major factor for effectiveness depending on the purposes. In this study, PLGA-poly(ethylene-alt-maleic anhydride) (PEMA) micro/nanoparticles were prepared using a double emulsion-solvent evaporation method, and the particle size was controlled by the composition of PLGA and PEMA. The effect of the size of PLGA micro/nanoparticles on vaccination efficiency will be evaluated using the diverse size of PLGA particles.