Enhancement of proliferative effects of basic fibroblast growth factor with hyaluronic acid hydrogel by light-induced thiol-ene reaction
발표자
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초록
내용
The cornea of the eye is at high risk of infection from the outside. As a general treatment method, eye drops are used, however in this case, the residence time of drug in eyes is very short. Therefore, new ways to extend the residence time are needed. Hyaluronic acid (HA) is a substance that has a healing effect on the cornea. HA hydrogel is produced using thiol-ene reaction. Thiol-ene reaction is biocompatible and is proceeded with HA substituted with thiol and alkene through blue light as a light source and riboflavin phosphate as a photo initiator. The hydrogel is expected to increase the residence time of HA in eyes and act as a drug carrier. Therefore, it is possible to develop an efficient treatment method compared to the existing treatment methods. By developing a hydrogel equipped with a drug delivery system, we will develop an efficient alternative treatment for corneal tissue regeneration.