Optimization of the preparation parameters of Escitalopram loaded PLA/PLGA microspheres for sustained release
발표자
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초록
내용
We developed escitalopram loaded Poly (D,L-lactide) (PLA) / Poly (D,L-lactide-co-glycolide) (PLGA) microspehres for sustained release of escitalopram(ET). ET is a selective serotonin reuptake inhibitor used to treat major depressive disorder (MDD). In the previous study, 1-hydroxy-2-naphtoic acid was added to solve the problem caused by phase separation between ET and polymer. The purpose of this study is optimization of ET loaded PLA/PLGA microsphere formulation (solvent volume, polymer composition and initial drug loading). The microspheres were prepared by O/W(Oil in water) solvent evaporation method, and were characterized using SEM, HPLC, Optical microscope, DSC and in vitro release test. ETM-3 (solvent volume 1.0 mL, ratio of lactic acid and glycolic acid in polymer 75:25) showed high encapsulation efficiency and sustained release behavior. From the results, ET loaded microspheres are expected to be suitable for deliver ET and the treatment of MDD over long periods.