Sustained release characterization of donepezil-loaded PLGA microspheres addition to glycolic acid as a release retardant.
발표자
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초록
내용
Donepezil(DP) is an esterase inhibitor and is widely used in Alzheimer's disease. Donepezil loaded Poly (D,L-lactide-co-glycolide) (PLGA) microsphere has a problem in that the drug is rapidly released at an early stage. The purpose of this study is to find the optimal conditions for the release of donepezil loaded microspheres by adding glycolic acid, one of the salts that can be used as a release retardant. PLGA microspheres were prepared using O/W emulsion solvent evaporation, and were prepared by glycolic acid molar ratio, initial drug content, and polymer type. Quantitative analysis was performed using HPLC, and morphological observation was performed using an optical microscope and SEM. Release behavior was confirmed by an in vitro test. As a result, DP75/GA(0.4)-753H showed high encapsulation efficiency and sustained release behavior. Therefore, it is expected that glycolic acid could be used for the development of PLGA sustained-release microsphere injection.