Targeted cancer therapy using PDT-based self-assembled nanoparticles that can be selectively activated in tumors by visible-light
발표자
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초록
내용
Among anti-cancer technology, the therapeutic effect of photodynamic therapy (PDT) in cancer treatment is highlighted due to high efficacy of PDT using reactive singlet oxygen. However, poor tissue penetration of light has limited the effectiveness of PDT in the clinic. Therefore, in this study, we newly have developed noble light-induced apoptosis activatable nanoparticles that consists of the photosensitizer (Ce6), caspase 3 cleavable peptide (DEVD), and monomethyl auristatin E (MMAE). Compared with conventional PDT based on high-energy irradiation, this novel PDT therapy uses lower-energy irradiation to induce apoptosis of cancer due to activation of caspase 3. As a result, the activation of MMAE in the Ce6-DEVD-MMAE nanoparticles amplified the cytotoxic effect at the tumor site. Therefore, This remarkable PDT-based therapeutic strategy can be used to treat various solid tumors.