Soft nanoliposomes as an effective drug carrier in breast cancer
발표자
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초록
내용
Nanoliposomes (NLPs) as novel drug carriers have been physically and chemically modified for better pharmaceutical functions. The effect of NLPs elasticity on cell uptake has been explored to a lesser extent. We successfully designed NLPs with varying elasticity while other physical and chemical properties of NLPs were kept consistent. Using the atomic force microscope-based force spectroscopy, the NLPs with aqueous core exhibit the lowest Young’s modulus while the NLPs with calcium crosslinked alginate core exhibited the highest Young’s modulus. We found that the soft NLPs exhibited higher permeability in human umbilical vein endothelial cells than the hard counterparts. We also observed the enhanced cellular internalization of the soft NLPs in breast cancer cells compared with the hard NLPs. We concluded that the softness of nanoparticles plays a fundamental role in facilitating the drug uptake and efficacy in breast cancer in vitro.