Development of chitosan-based hydrogels embedded with poly(N-isopropylacrylamide) nanogels for thermoresponsive controlled drug delivery
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초록
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A facile synthetic strategy was developed for the preparation of thermoresponsive nanocomposite hydrogels comprising crosslinked chitosan networks and poly(N-iso-propylacrylamide) nanogels. The p(NIPAAm) nanogels were synthesized via emulsion polymerization and introduced into methacrylamide CS (MC) solution. The free-radical initiated crosslinking reaction of MC produced nanogel-embedded hydrogels. Notably, thermoresponsive drug-release was achieved without unwarranted modification of the hydrogel’s dimension and shape, although an increase in temperature caused the collapse of the p(NIPAAm)nanogels. The thermoresponsive property of the investigated nanocomposite hydrogel is beneficial and may offer broad opportunities for drug temperature-triggered release for clinical applications.