Synthesis of Super-Hydrophobic Monomer based Polymeric Micelles forpH-Responsive Drug Delivery Systems
발표자
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초록
내용
To overcome drawback of the drug, releasing the drug at a desired site is essential. Due to the acidic pH of tumor cell, pH-responsive acetal bond can be exploited as a key chemistry for stimuli-responsive drug delivery systems (DDS). In this study, we synthesized the novel diblock copolymers composed of super-hydrophobic epoxide monomer of cyclohexyloxy ethyl glycidyl ether (CHGE) via anionic ring-opening polymerization (AROP) using organic superbase, t-BuP4. After the polymerization, the acetal group in PCHGE was deprotected to hydroxyl group in acidic conditions and converted to biocompatible polyglycerols. The mPEG-b-PCHGE were carefully characterized by 1H NMR, GPC, and DSC. The mPEG-b-PCHGE was able to self-assemble into a polymeric micelles in aqueous conditions. The selective cleavage of the acetal bond under acidic conditions led to a sustainable release of the drug. We anticipate this super-hydrophobic monomer based polymeric micelles will provide new means for a smart DDS.