The drug loading/releasing capability of glutathione-responsive peptide amphiphile vesicles controlled by positionable disulfide-bridges
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In anticancer drug delivery system, delivering and releasing the drugs to the target tumor cells is challenging due to systematic toxicity and side effects on normal cells. The self-assembly of peptide amphiphiles (PAs)-based vehicles have garnered attention due to their biocompatibility and a dual loading capability for hydrophilic and hydrophobic payloads. However, controlled stability in physiological media remains a challenge for efficient drug encapsulation and release. Here, the glutathione-responsive drug-releasing vesicles were developed by self-assembly of PA with cysteine which can form disulfide-linkages. The PA vesicles demonstrated different drug loading capacities and releasing efficiencies as functions of the location and number of disulfide-linkage during assembly. This research provide a biocompatible peptide design for the synthesis of efficient drug-delivery vehicles and serve as a solid foundation for further nanocarrier developments for biomedical applications.