Upper critical solution temperature behavior of (phenylthio)acetic acid and poly(ethyleneimine) mixture and their temperature-dependent release from monoolein cubic phase
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초록
내용
A new phenomenon has been found that the (phenylthio)acetic acid(PTA) could be conjugated with poly(ethyleneimine)(PEI) to form nanoparticles in aqueous solution. It is possibly dominated by the electrostatic attraction between the carboxyl group of PTA and the amino group of PEI. Meawhile, the hydrophobic interaction inside the PTA also plays an important role. Besides, during the experiment we found that the self-assembly of PEI/PTA exhibited reversible UCST behavior in the temperature range from 20--50 degrees when the molar weight of the amino group of PEI to the molar weight of carboxyl group of PTA was 4:6 or 5:5 in PBS buffer(10mM, pH 7.4). What’s more, the monoolein cubic phase which was temperature-responsive was prepared. By containing the PEI/PTA conjugate and FITC-dextran(MW:10,000) within its structure. The release of dye from the cubic phase containing PEI/PTA at 45 degrees is obviously higher than the release at 25 degrees.