Development and characterization of propolis extract, camellia oil extract, oil soluble licorice Extract encapsulated polymeric micelle nanoparticle material
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초록
내용
Propolis extract, Camellia oil extract, and oil soluble licorice extract are difficult to be applied due to its low water solubility despite its well-known efficacy. In this study, polymeric nanomicelle material containing three extracts was prepared using biocompatible polymer. Prepared nanomicelle material was stable when stored at 40°C for 3months and RT for 6 months. The particle size analysed by DLS was 17nm to 21nm. The encapsulation rate of propolis and glabridin analyzed by HPLC were 99.49% and 98.93% each. Total skin permeability after 24 hours was 8.67% for the control group and 18.87% for the polymeric nano micelle material group. Tyrosinase inhibition assay, DOPA oxidation inhibition assay, melanin production test assay, hyaluronic acid test assay in the cell, synthesis of collagen and inhibition of collagenase assay were conducted and the result of nanomicelle group were higher in comparison. This study was funded by Korea Institute for Advancement of Technology(P0006163)