Enhancement of ROS quantum yield of photosensitizer by chemiluminescence resonance energy transfer for photodynamic cancer therapy
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초록
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Chemiluminescence (CL) resonance energy transfer (CRET) based-nanoparticles (CRET-NPs) have studied for cancer imaging. The peroxalate is one of the CL energy donors in responding to H2O2-enriched in tumor tissue. As the CRET-NPs can deliver photosensitizer (PS) with peroxalate, which plays a role as CL energy acceptor, much effort has devoted to applying for photodynamic therapy (PDT) by its luminescence property. However, not only the power of CL is not enough to activate PS solely, but O2-dependency of type II photochemical reaction of conventional PDT also has a limit to applying the hypoxic region of tumor tissue. Thus, it is necessary to develop strategies to enhance ROS quantum yield in an O2-independent manner for cancer PDT. Herein, we report CRET-NPs to achieve quantum yield-enhanced PS through both electron transfer for an O2-independent type I photochemical reaction and CL for an O2-dependent type II photochemical reaction in responding to tumor-microenvironment.