Injectable, biocompatible conjugated catechol chitosan hydrogels with Iron inducement and EDTA treatment at different conditions
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Chitosan (CS) is a natural polycationic polysaccharide and pH sensitive polymer with incomplete deacetylation from claiming chitin. It is a guaranteeing material in terms of pharmaceutical, chemical, and sustenance industry due to its exceptional structure including reactive –OH and –NH2 groups. In this study, a catechol-modified chitosan (CCS) for an eminent level for substitution was synthesized and propelled by marine mussel cuticles in place on research those intricate connections between Fe3+ and catechol under acidic conditions. The hydrogels showed enhanced cohesiveness and shock-absorbing properties at lower pH and ethylenediamine-tetra-acetic acid (EDTA) treatment due to coordinate bonds. Thus, the gelation time, rheological properties and the morphologic aspects were elucidated to describe those cross-linking components and the physical properties of the chitosan backbones and hydrogel frameworks.