Gene delivery and drug delivery study based on synthesized biodegradable and biocompatible polyurethane double emulsion nanoparticles.
발표자
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초록
내용
In this study, gene carrier nanoparticles with minimal toxicity and high transfection efficiency were fabricated from biodegradable polymer (L-tyrosine polyurethane, LTU), which was pre-synthesized from desaminotyrosyl tyrosine hexyl ester (DTH), and polyethylene glycol (PEG) and used to evaluate their potential biological activities molecular controlled release and transfection studies in LX2, HepG2, MCF7 cells. And the second study was progressed with biodegradable polyfumarateurethane (PFU) for use as a bupivacaine delivery vehicle, synthesized using di-(2-hydroxypropyl fumarate) (DHPF), polyethylene glycol (PEG) and 1,6-hexamethylene diisocyanate (HMDI), was designed to be degradable through the hydrolysis and enzymatic degradation of the ester bonds in its polymer backbone. Using double emulsion techniques, both nanoparticles were fabricated encapsulating the drug (gene), to avoid the immune system their surface was modified with PEG.