Tannin-based nanoformulation for stabilization of paclitaxel in aqueous medium
발표자
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초록
내용
Nanoformulation of anti-cancer drugs with polymeric carriers has shown great promise to improve the biostability and therapeutic efficacy. In this study, we utilized one of abundant tannin, tannic acid (TA), to solubilize a chemotherapeutic agent, paclitaxel (PTX), in aqueous medium. The TA/PTX complex further formulated with a hydrophilic biopolymer, poly(ethylene glycol) (PEG) to increase the biostability. We found that stable colloidal nanoparticles with a hydrodynamic size of ~150 nm in diameter was successfully formed, which was water-dispersed up to 7 days without changes in size. We expect the synthesized nanoformulation of PTX can be an effect therapeutics in chemotherapy. *This work was carried out with the support of “Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01323201)” Rural Development Administration, Republic of Korea.