Guiding Tissue Regeneration of Rabbit Bone Defects using Silk Fibroin-Poly(glycolic acid) Hybrid Scaffolds Fabricated by Electrospinning and 3D Printing Techniques
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초록
내용
Tissue engineering aims regeneration of defected biological tissues and organs by combining cells, scaffolds, and growth factors. We prepared patient-customizable guided bone regeneration (GBR)/guided tissue regeneration (GTR) hybrid scaffolds by electrospinning and 3D printing techniques. Poly(glycolic acid) (PGA) scaffolds were fabricated using a 3D printer. The microstructure of silk fibroin and PGA hybrid scaffolds was observed by SEM. Cell proliferation of osteoblasts on a PGA scaffold was analyzed. Rabbit bone defect model was used for animal test. Regenerated tissues were analyzed by H&E staining and micro-CT. Silk fibroin nanofiber-PGA scaffold groups showed significant regeneration of bone compared to control groups. The silk fibroin nanofiber-PGA scaffold construct will provide a prospective approach for regeneration of bone defects.