Korea-Taiwan Joint Symposium: Advanced Polymer Science and Engineering (English)
발표 구분
초청강연
제목
Synthesis and Hydrogelation of Polypeptide-Based Polymers
발표자
()
초록
내용
Polypeptide-based copolymers recently have attracted increasing interest due to their biodegradability/biocompatibility, ordered chain conformation, stimuli-responsiveness, and possibly biological functions. We report the synthesis and hydrogelation of block copolypeptides in solution. The hydrogelation was determined by the packing of the polypeptide assemblies, dictated by the balance between the intermolecular hydrogen bonding interactions and charge repulsion exerted respectively by sheet-like and positively charged polypeptide segments. These noncovalent interactions can be manipulated by varying polypeptide chain composition and conformation as well as topology, which governed their critical gelation concentration, gel molecular assembly, and gel mechanical property. This study reveals that sheet-like segments can trigger the self-assembly and hydrogelation of polypeptides.