Melanin-like Nanoparticles for Multimodal Synergistic Therapy of Cancer
발표자
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초록
내용
Cancer is the reason for one in six deaths, and the number of new cases increased to 18 million in 2018. The development of more effective and less toxic drug delivery systems for the treatment of cancer is crucial due to the serious side effects of currently used clinical procedures. Recently, nanoparticles became attractive candidates in drug delivery research by overcoming several limitations of conventional therapies. Melanin is a natural dark pigment with good biocompatibility, biodegradability, intrinsic photoacoustic properties, and the ability to bind drugs. In this study, a melanin-like nanoparticle-based drug delivery system was designed for near-infrared light controlled trimodal therapy in which photodynamic therapy, photothermal therapy, and chemotherapy are combined to produce synergistic therapeutic effects. The in vitro anticancer effect of MNPs was investigated in terms of photothermal efficiency, stimuli-responsive drug release, and therapeutic efficacy.