Injectable Hydrogels Scavenging Reactive Oxygen Species for Wound Management and Tissue Repair
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초록
내용
Injectable hydrogels have been widely used as wound dressing because they can maintain a moist wound microenvironmet that protect the wound from bacterial infection and absorb large amount of exudates. However, the excessive reactive oxygen species (ROS) at the injured sites can impair cutaneous wound healing by triggering deleterious processes (e.g., necrosis, inflammation and fibrotic scarring). Herein, we developed an injectable hydrogel with highly free radical scavenging properties, using the antioxidant gallic acid conjugated gelatin (GGA). The hydrogels were rapidly formed within 10 sec via HRP-catalyzed cross-linking reaction. The physico-chemical properties and free radical scavenging activities of hydrogels were characterized and controlled. The effect of hydrogels on promoting the wound healing and repair was also investigated in vivo, using a full-thickness mice skin defect model. Acknowledgement: NRF-2018R1A2B2004529 & 2019R1A6A1A11051471