On-site Fabrication of Injectable Biodegradable <SUP>131</SUP>I-Labeled Microgels for Local Radiotherapy
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초록
내용
Nuclear medicine is an important clinical options for diagnostic imaging and disease treatment. Encapsulating radioisotopes in injectable hydrogels is ideal for achieving long-term, low-dose radiotherapy by targeting radionuclides to tissues or organs. However, difficulties in the on-site fabrication of radioactive hydrogels during treatment and unpredictable radiation levels at the target site are major obstacles to clinical use. Here, we developed a strategy that facilitates the on-site fabrication of radioactive microgels requested in clinical environment using a 131I-labeled hyaluronic acid (HA) and a microfluidic system. This approach allows for on-site fabrication of injectable, radioactive, biodegradable (IRB) HA microgels, enabling immediate therapeutic application with improved local retention. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 min and localizing them beyond 1 week to minimal off-target biodistribution.