Self-Assembly of Two-Tailed Tadpole-Shaped Amphiphilic Copolypeptides
발표자
()
초록
내용
Smart amphiphilic polypeptide self-assembly derived nanoparticles offer unique control over molecular behavior for biomedical engineering applications. In this work we have synthesized a two-tailed tadpole-shaped poly(N-isopropylacrylamide)20-block-(cyclic-poly(L-lysine)25)-block-poly(N-isopropylacrylamide)20 amphiphilic copolymer utilizing reversible addition-fragmentation chain transfer polymerization (RAFT), click cyclo addition reaction and ring-opening polymerization of α-amino acid N-carboxyanhydrides. The polymer was characterized using 1H nuclear magnetic resonance and Fourier-transform infrared spectroscopy. Final amphiphilic copolymers were self-assembled into spherical micelles, two-dimensional square, cubic, rods and thread-like fiber morphologies under various self-assembly conditions and confirmed using transmission electron microscopy. The selfassemblies were controlled by the factors such as type of solvent ratio of of the solvents and polymer concentration.