Injectable and self-healing Fmoc-diphenylalanine(Fmoc-FF) hydrogels for sustained drug release
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내용
Self-assembled hydrogels from Fmoc-diphenylalanine(Fmoc-FF) have potential application for drug delivery due to their biodegradability, biocompatibility, injectable and self-healing property. In this study, the hydrogels were prepared via electrostatic interaction between negative charged Fmoc-FF and positive charged glycol chitosan(GC) in physiological pH. GC has excellent advantages for biomedical applications, such as low toxicity, antibacterial, biodegradability. Doxorubicin(DOX) is an anti-tumor drug. indomethacin(IDM) as non-steroid anti-inflammatory drug has low toxicity and synergetic effect with DOX. We investigated morphology, mechanical properties and in vitro release of DOX and IDM were characterized for hydrogels as a function of composition.