The biocompatible neural interface coated with Heparin/Substance P-conjugated PLCL promotes neuronal development and limits astrogliosis
발표자
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초록
내용
Most neuroprosthetic devices implanted into the central nervous system (CNS) face limitations in longevity and functional reliability due to undesired inflammatory host tissue response initiated upon device insertion. At the implant site, activated microglia, reactive astrocytes, macrophages form glial sheath that can encapsulate and isolate the electrode from the surrounding tissue. In addition, neuronal loss and neurite degeneration occur surrounding the electrode due to inflammatory response. As a result, signal recording becomes inaccurate and the device becomes unusable. Ideally, an implanted devices would minimize glial reactivity and proliferation in the vicinity and support neuron adhesion and neurite outgrowth. Thus, we developed heparin or SP conjugated PLCL polymer coating to support neuronal adhesion and differentiation and to suppress activation of microglia and astrocytes.