Micropattern-based multichannel nerve conduit with stem cell recruitment ability
발표자
()
초록
내용
Guided regrowth of thousands of nerve fibers in a regenerative environment improves regeneration of peripheral nerve and spinal cord injury. Although current clinical treatments and a variety of studies exist, the development of nerve-guided conduits with desirable properties, including controllable size, hundreds of micro-channels of neural tissue-like and host stem cell recruitment, is still a challenge. In this work, micropattern-based manufacturing methods work with fixation on key materials of stem cell recruitment factors to produce hundreds of microchannels with stem cell recruitment ability and resizable nerve-guided conduits. A number of functionalized microchannels implanted in peripheral nerve damage and spinal cord injury in rats align the regrowth of nerve fibers and mobilize more host stem cells to improve functional regeneration capacity.