3D bioprinted gelatin-methacrylate hydrogels containing poly(lactic-co-glycolic acid) nanofiber fragments
발표자
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초록
내용
Hydrogel is an optimal biological environment for cell encapsulation. A fiber-reinforced gelatin-methacrylate (gelMA) hydrogel bioink that can improve the compressive modulus and cell proliferation using poly(lactic-co-glycolic acid) nanofiber fragments (PLGA-NF) as an artificial extracellular matrix to build specific soft tissues. The microstructures of the nanofiber fragments were observed via SEM. The degree of substitution of synthesized gelMA was investigated considering the mole ratio of MA and gelatin. The compressive modulus of hydrogels was measured using a texturometer. Cell viability of the encapsulated fibroblast was confirmed using live-dead stains and phalloidin-DAPI stains. Cell proliferation in bioprinted gelMA/PLGA-NF hydrogels was increased in comparison to the control groups. The combination of hydrogel bioink with nanofibrous fragments will be a critical foot step in the field of 3D bioprinting.