Oral GLP1 gene delivery by bile acid based non viral gene delivery carrier to treat type II diabetes mellitus
발표자
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초록
내용
Genetic therapy is a treatment technique that delivers the target gene based on genetic manipulation which directly delivers the carrier containing the patient's required gene. The concept of oral gene therapy has already been proven, but non-viral gene delivery through gastrointestinal track is experiencing many difficulties due to low gene expression. There are also difficulties in effectively controlling intestinal enzymes and microbes and decomposition by digestive fluids. However, the active transport system by bile acid has the ability to pass through intestinal epithelial cells, which can solve the problem of absorption efficiency such as above because the intestinal epithelial cells have bile acid receptors. We have newly fabricated the oral gene delivery carrier, which promotes absorption into the small intestine by making the gene core using cationic material and calcium salts and coating with an anionic substance which synthesized with chondroitin sulfate A and bile acid.