Supramolecular Injectable Hyaluronate Hydrogels for Cartilage Tissue Regeneration
발표자
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초록
내용
Mesenchymal stem cells (MSCs) have been widely investigated to repair damaged cartilage tissues for the treatment of arthritis. Despite these great efforts, the difficulty in the spatiotemporal control of delivered cells has limited the further clinical development with rapid clearance. Here, we developed injectable hyaluronate (HA) hydrogels to encapsulate MSCs for controlled cartilage tissue regeneration based on the supramolecular chemistry between β-cyclodextrin (β-CD) modified HA (HA-CD) and adamantane (Ad) modified HA (HA-Ad). The spatiotemporally controlled delivery of MSCs from the supramolecular HA hydrogels resulted in the statistically significant chondrogenic differentiation and extracellular matrix (ECM) deposition in vitro and in vivo. Taken together, supramolecular HA hydrogels might be successfully harnessed as an injectable delivery system of MSCs for cartilage tissue regeneration and other tissue engineering applications.