In vitro photodynamic effects of dectin-1 receptor targeted-photoactivatable nanoagents on atherogenic cells
발표자
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초록
내용
Atherogenic cells such as macrophages and foam cells have critical roles in the initiaion and progression of atherosclerosis and have been considered an important biomarker for targeted imaging and inflammatory-disease therapy. It is known that these cells express dectin-1 receptos. Here, we prepared the specific dectin-1 receptro targetable and photoactivatable nanoagents by physical loading of chlorin e6 (Ce6) into single strand beta-glucan (Glu). Glu/Ce6 formed nano-sized particles and generate single oxygen under laser irradiation. Also, it was internalized via receptor medicated endocytosis and notably caused apoptosis of activated macrophages and foam cells under laser irradiation.