Various stimuli-responsive hydrogels were used in various fields of cutting-edged technologies, such as biomimetic nanomaterials, sensors, tissue engineering, and drug delivery systems. In this study, we have designed poly(2-alkyl-2-oxazoline)-based polymeric hydrogels as a multimodal stimuli-responsive materials. POxs show unique thermoresponsive phase transition behavior via lower critical solution temperature (LCST). Furthermore, POxs are excellent biofunctional materials owing to their superior biocompatibility. During the preparation of POx-based hydrogel, we used azobenzene groups as the crosslinking agents. Thus obtained hydrogel showed thermoresponsive phase transition as well as pH dependent color changes.