Biodegradable Polymer-based Radiopaque Micropaticles for Transarterial Chemoembolization
발표자
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초록
내용
Transarterial Embolization (TAE) is one of the therapeutic methods for hepatocellular carcinoma (HCC), blocking blood vessel in tumor with embolic materials. Conventional embolic beads, however, are usually non-biodegradable and have no x-ray visibility, which cause risk of medical malpractice and difficulty in repetitive injection. Therefore, it is essential to develop advanced embolic bead with biodegradability and radiopacity itself. In this research, well-calibrated microparticles (MPs) were formed. Diameter and size distribution of the final product were analyzed with optical microscope. The x-ray visibility was determined with real-time C-arm device. The diameter of MPs was about several hundred micrometers, and it showed narrow size distribution. MPs were determined to have enough x-ray attenuation property to be visualized with C-arm device. In conclusion, we confirmed the potential of these biodegradable polymeric MPs to be applied to cancer therapy.