Synthesis and Properties of Novel Multiple-hydroxy Polyaspartamide and its Cross-linked Gels
발표자
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초록
내용
In this work, the synthesis and characterization of multiple-hydroxy polymer, poly(N-2,3-dihydroxypropyl aspartamide) (PDHPA), and its crosslinked gels are discussed. PDHPA has several valuable properties including biodegradability, high water-solubility, excellent biocompatibility, and good adhesive property. Additionally, the vicinal dihydroxy functional group can be oxidized and coordinate with some metal cations to form complexes. Owing to its unique chemical structure, PDHPA features a useful platform to combine with other materials and to prepare different sort of hydrogels. Here, PDHPA was crosslinked by using several different reaction mechanism and the characteristics of resulting gels were elucidated. This newly developed multi-hydroxyl polymer and gels, having non-toxic biocompatible nature, have potential uses in biomedical application fields.