Dual-crosslinked Chitosan Aerogel for Wound Dressing Prepared by Non-acid Condition
발표자
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초록
내용
Aerogel is a porous material used in various fields including biomedical engineering. Aerogel for wound dressing requires biocompatibility and structural stability, as well as high absorbency. Herein, chitosan-based aerogel for wound dressing was prepared by dual crosslinking in non-acid condition. Chitosan was dissolved in 1-butyl-3-methylimidazolium chloride (BmimCl). The hydroxyl groups were covalently crosslinked by epichlorohydrin (ECH) while the amino groups were ionically crosslinked by itaconic acid (IA). Each crosslinking of the aerogels was analyzed using FT-IR spectra and solid-13C NMR. The concentrations of ECH and IA significantly influenced on the water absorption capacity of the aerogel, with the highest swelling ratio of over 1200 %. The aerogel showed low toxicity against human cells and good antibacterial function against Gram-positive and Gram-negative bacteria strains. The prepared aerogel shows potential as a wound healing matrix.