Study of cell movement and proliferation by the control in physical and/or chemical properties of the substrate
발표자
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초록
내용
The surface properties of biomaterials are important issues in cell culture. Especially, surface-adherent cells are affected by the physical and chemical properties of the surface material on their activities such as cell adhesion, migration, and proliferation. We fabricated micro-pillar structured substrates and applied various polymer coatings to use them as cell culture plates. Cells including neuronal cells were cultured on these substrates and monitored their activities. Depending on the surface structure and the wettability, cellular morphology and growth were changed. Besides, cells that were grown for 3 days on microstructured surfaces showed special morphology even after transferred to a general flat dish. These results present more understanding of the chemical and physical influence of cell culture condition to cell function.