Substrate-Independent Antibacterial Coatings by Zwitterionic L-DOPA
발표자
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초록
내용
We synthesized a zwitterionic 3,4-dihydroxy-L-phenylalanine (L-DOPA) derivative (ZW-DOPA) containing both catechol and amine groups, and examined its antibacterial effect. NaIO4-induced ZW-DOPA coatings could be formed onto various substrates, such as titanium, gold, stainless steel, and nylon. The surface coatings were characterized by ellipsometer, contact angle goniometry, atomic force microscopy, and X-ray photoelectron spectroscopy, demonstrating the successful ZW-DOPA coatings. Interestingly, the static water contact angles of the 11°, regardless of the initial values of uncoated substrates. Compared to controls, ZW-DOPA-coated substrates strongly inhibited the bacterial adhesion on surfaces, showing the antibacterial effect. Such effect would be induced the strong hydration of the ZW-DOPA coatings