Barium Titanate Nanoparticles/Hyaluronate-Rose Bengal Conjugate for Noninvasive Photochemical Tissue Regeneration
발표자
()
초록
내용
Barium titanate nanoparticles(BTNP) are widely used in the field of photomedicines, because they can convert near infrared(NIR) light into visible light owing to second harmonic generation(SHG). However, finite depth of light penetration limits the treatment of deep skin wounds. Here, we developed barium titanate nanoparticle/hyaluronate-rose bengal (BTNP/HA-RB) conjugates for deep tissue regeneration with NIR light illumination. Compared to invasive tissue treatments, BTNP/HA-RB could be delivered noninvasively into the collagen layer of the dermis and provide visible green light upon NIR light. The activated RB by the green light induced radicals for crosslinking of dissected collagen matrix. The formation of BTNP/HA-RB conjugates were characterized by Absorbance spectrum and Photoluminescence measurement. An in vitro tensile strength test of incised skin tissues and an in vivo animal wound closure rate test confirmed the efficient tissue regeneration effect of BTNP/HA-RB conjugates.