Fabrication of Phospholipid- and Block Copolymer-based Artificial Sensory Organ Arrays on Chips
발표자
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초록
내용
The bio-sensory organs of living creatures have evolved to have the best sensing performance. Among them, microvilli on the tongue and cilia on the olfactory system are 3-dimensional protrusions that have large surface areas to accommodate a large number of membrane proteins such as ion channels and G-protein coupled receptors, enabling high sensitivity and specificity to target molecules. From the perspective of mimicking these systems, herein, we fabricated solvent-free, 3-dimensional, free-standing phospholipid and block copolymer structure arrays, and demonstrated their structural advantages for efficient and rapid protein reconstitution, compared to 2-dimensional structures. Finally, we detected a neurotransmitter, serotonin, using the proposed structures as a sensing platform mimicking bio-sensory organs.