Artificial photosynthesis has been devised and investigated in pursuit of solving 21st century’s energy problem. Despite such advances in recent decades, applying the technology in real life is still a challenging subject for the scientists. As the term “artificial photosynthesis” stems from mimicking the natural photosynthesis, we can learn from the nature’s strategies which have been evolved for 3.4 billion years. This talk highlights our recent progress on developing highly efficient and robust artificial photosynthetic systems by mimicking the important strategies of natural photosynthesis. Starting with a brief description of photosystem II in natural photosynthetic autotrophs, two relevant bioinspired strategies are discussed in this talk: i) supramolecular chemistry, ii) accumulative charge transfer, and iii) self-healing. Finally, remaining challenges and perspectives for future development of artificial photosynthesis will be discussed.