pH-responsive polymer-coated silica–titania hollow nanoparticles for controllable drug release
발표자
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초록
내용
Poly(acrylic acid) (PAA)-coated silica–titania hollow nanoparticles (PAA-HNPs) are synthesized and applied as nanocarriers for the smart drug delivery system. Since the PAA-HNPs have high biocompatibility and low cell–toxicity as well as consist of hollow structure that can accommodate drug molecules, the prepared PAA-HNPs are suitable materials for drug delivery systems. Furthermore, the PAA is adopted as a coating substance because of its pH-responsive characteristics. To examine the pH-responsive characteristics of PAA, dye molecules are loaded into the hollow nanoparticles and induced to be released in various pH conditions. The analysis results demonstrate that the PAA-HNPs show pH-dependent properties. Acknowledgement: This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (No. 2019R1C1C1007578) and the Technology Innovation Program (20004627) funded By the Ministry of Trade, Industry & Energy(MOTIE, Korea).