In modern society, it is important not only to diagnose and treat the disease, but also to improve the quality of life, such as hair loss, acne and cosmetic surgery. Among them, hair loss is a common disease with a high proportion of adult men. Recently, these disease has been also increasing in women steadily. First, for this experiment, microneedles(MNs) were prepared by combining liquid hair growth factors (M(K)) according to concentrations (0%, 1%, 3%, 5%). And the experiment was conducted to check the skin delivery potential and stability of the factors. The morphology of the prepared MNs was confirmed using a scanning electron microscope (SEM), and skin permeability was measured using a porcine skin. Variation in viscosity was confirmed according to the difference in concentration. The efficacy of M(K) and cytotoxicity of MNs bound to MNs were analyzed using the MTT-assay. Finally, the stability of the factor component bound to MNs was confirmed by XPS.