Surface Sealable Poly(ε-caprolactone) (PCL) Hollowed Nanoparticles and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Opening System for Drug Release.
발표자
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초록
내용
An easy loading system using NIR Light-Triggered Opening Property for Drug Release is introduced. It consists of hollowed PCL nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings not only enhance the connectivity between the interior and the exterior but enable the easy loading of drug molecules into the interior voids. When the photothermal agent exposures to a NIR light irradiation, it generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, and consequently, the instant release of the encapsulated drug molecules through the pores. The activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.