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「Macromolecular Research」 목차 고분자 과학과 기술 제 32 권 2 호 2021년 4월 201 Release Behavior of Telmisartan/ Amlodipine Combination Drug According to Polymer Type Suyoung Been, Jeongmin Choi, Pil Yun Kim, Won Kyung Kim, Alessio Bucciarelli, Jeong Eun Song, and Gilson Khang* Macromol. Res., 29, 217 2021 Patients at risk for hypertension with comorbidities such as diabetes and metabolic syndrome often require two or more antihypertensive drugs to lower blood pressure. Telmisartan and amlodipine are widely known drugs to treat hypertension. A solid dispersion containing a water-soluble polymer was prepared to make the absorption rate of telmisartan, a poorly soluble drug, similar to that of amlodipine, a soluble drug. Polyvinylpyrrolidone K30, polyethylene glycol 6000, and poloxamer 407 were used. The encapsulation of the solid dispersion was analyzed by differential scanning calorimetry, X-ray diffraction, and high-performance liquid chromatography. The reduced flow...
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