POS5-0703
Metal Synapses for Fingerprinting Amyloid-β Assembly-State-Dependent Plasticity Distortion
When and Where
Nov 30, -0001
00:00 - 00:00
Presenter(s)
Jang hwandong (Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea)
Co-Author(s)
Abstract
Amyloid-β (Aβ) exists in multiple assembly states, including monomers, oligomers, and fibrils, each with distinct pathological relevance. Here, we propose a voltage-driven gel-metal interface that behaves as an artificial synapse for distinguishing Aβ assembly states through coupled electrical and optical responses. Under voltage pulsing, a redox-active interface undergoes growth and dissolution, producing history-dependent (synaptic) plasticity in optical contrast, retention, switching kinetics, current peaks, hysteresis, and conductance. Because this plasticity is sensitively distorted by the molecular and supramolecular state of Aβ at the interface, analyzing multiple correlated parameters, rather than a single signal intensity, fingerprints each assembly state. This system offers a bio-inspired strategy for translating subtle peptide-assembly differences into measurable, assembly-state-dependent synaptic responses.
